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Tim G. de Meij, Ilhame Ben Larbi, Marc P. van der Schee, Yvette E. Lentferink, Tamara Paff, Jochim S. Terhaar sive Droste, Chris J. Mulder, Adriaan A. van Bodegraven and Nanne K. de Boer Electronic nose can discriminate colorectal carcinoma and advanced adenomas by fecal volatile biomarker analysis: proof of principle study International Journal of Cancer 134

Version of Record online: 2 SEP 2013 | DOI: 10.1002/ijc.28446

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The analysis of volatile organic compounds (VOCs) in feces is a promising approach to gastrointestinal disease detection. In this investigation, an electronic nose (or “e-nose”) was used for fecal gas analysis of stool samples collected from healthy controls and patients with colorectal carcinoma or advanced adenoma. VOC profiles for colorectal carcinoma and advanced adenoma were found to differ significantly from control profiles. The opportunity for scalability for high-throughput capacity makes e-nose fecal gas analysis especially appealing as a possible screening tool for the detection of colorectal malignancies.

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