Andrew R. Tsen, Patrick M. Long, Heather E. Driscoll, Matthew T. Davies, Benjamin A. Teasdale, Paul L. Penar, William W. Pendlebury, Jeffrey L. Spees, Sean E. Lawler, Mariano S. Viapiano and Diane M. Jaworski Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma International Journal of Cancer 134
Cancer is associated with global decreases in acetylation and aerobic glycolysis, yet acetate supplementation as a therapeutic approach has not been studied extensively. This study shows that aspartoacylase, the enzyme that catabolizes N-acetyl-L-aspartate, the primary storage form of acetate in the brain, is reduced in glioma tumors. The food additive Triacetin (glyceryl triacetate) was found to induce growth arrest in oligodendroglioma- and glioblastoma-derived glioma stem-like cells and to potentiate the chemotherapeutic effects of temozolomide in orthotopic grafts. These preclinical data warrant further examination of Triacetin as a possible chemotherapeutic adjuvant in the treatment of glioma.
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