Teresa To, Claus Wall, Cornelia J. Baines and Anthony B. Miller Is carcinoma in situ a precursor lesion of invasive breast cancer? International Journal of Cancer 135
Carcinoma in situ (CIS) is considered to be a precursor of invasive breast cancer, though cumulative breast cancer risk following CIS diagnosis remains uncertain. Here, linking of the Canadian National Breast Screening Study (CNBSS) with cancer registries and a national vital statistics database shows that more than 80% of CNBSS women were free of invasive breast cancer at 20 years post-CIS diagnosis. Little more than 8% had died of breast cancer. The low probability of disease after CIS diagnosis suggests that CIS is not an obligate precursor lesion of invasive breast cancer.
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