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Yoshihiro Mikuriya, Hirotaka Tashiro, Shintaro Kuroda, Junko Nambu, Tsuyoshi Kobayashi, Hironobu Amano, Yuka Tanaka and Hideki Ohdan Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells International Journal of Cancer 136

Version of Record online: 4 AUG 2014 | DOI: 10.1002/ijc.29096

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Fatty liver is associated with hepatocellular carcinoma (HCC), but its exact role has been unclear. In this study, the authors found that HCC metastasis was increased in rats whose livers were steatotic. They also found that when hepatic stellate cells (HSCs) from rats with steatotic livers were co-injected with HCC cells into normal rats, the resulting tumors were significantly larger than when normal HSC cells were used. The increased levels of cytokines secreted by activated fatty-liver HSCs may enhance proliferation and migration of HCC.

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