Jinyuan Chen, Xia Dong, Jing Zhao and Guping Tang In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection Journal of Applied Toxicology 29
In present study, the acute toxicity of nano-sized TiO2 particles to adult mice was investigated by intraperitioneal injection. The data indicated that some TiO2 particles have entered spleen and caused severe lesion of spleen. Thrombosis was found in pulmonary vascular, which could be ascribed to the blocking blood vessel by TiO2 particles. In addition, titanium content examination showed that TiO2 nanoparticles could deposit in spleen, lung, kidney and liver, and transport between these tissues.
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