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Ricardo Brandão, Carmine I. Acker, Marlon R. Leite, Nilda B. V. Barbosa and Cristina W. Nogueira Diphenyl diselenide protects against glycerol-induced renal damage in rats Journal of Applied Toxicology 29

Version of Record online: 29 MAY 2009 | DOI: 10.1002/jat.1449

In this study we evaluated the effect of diphenyl diselenide (PhSe)2 on glycerol-induced acute renal failure in rats. Rats were pre-treated by gavage every day with (PhSe)2 for 7 days. In the eighth day, rats received an intramuscular injection of glycerol. Twenty-four hours afterwards, rats were euthanized and biological and histological parameters were determined. The results demonstrated that (PhSe)2 was able to protect against the alterations induced by glycerol in kidneys of rats.

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