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Anil Patri, Thomas Umbreit, J. Zheng, K. Nagashima, Peter Goering, Sabine Francke-Carroll, Edward Gordon, James Weaver, Terry Miller, Nakissa Sadrieh, Scott McNeil and Mel Stratmeyer Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice Journal of Applied Toxicology 29

Version of Record online: 22 JUL 2009 | DOI: 10.1002/jat.1454

EDS (energy dispersive X-ray spectroscopy), light dispersion, and electron microscopy were used to characterize titanium dioxide (TiO2) nanoparticles (approximately 112 nm in diameter). The distribution of these nanoparticles was then traced in tissue sections from mice following either subcutaneous (s.c.) or intravenous (i.v.) injection. TiO2 nanoparticles distributed primarily to the liver, spleen, and lung, but disposition was dependant on the route of administration (i.v. or s.c.).

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