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Arnida, Alexander Malugin and Hamidreza Ghandehari Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres Journal of Applied Toxicology 30

Version of Record online: 9 NOV 2009 | DOI: 10.1002/jat.1486

Using a series of gold nanoparticles with incremental increase in dimensions but varying geometries (spherical vs rods) we have evaluated the influence of shape, size, surface properties and concentration on cellular uptake, adsorption of proteins and toxicity in a human prostate cancer cell line (PC-3). In the range of 30–90 nm diameter studied, spherical particles of 50 nm in diameter without poly(ethylene glycol) (PEG) had the highest uptake. Surface attachment of PEG reduced cellular uptake of gold nanoparticles.

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