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Nancy A. Monteiro-Riviere, Steven J. Oldenburg and Alfred O. Inman Interactions of aluminum nanoparticles with human epidermal keratinocytes Journal of Applied Toxicology 30

Article first published online: 9 DEC 2009 | DOI: 10.1002/jat.1494

Aluminum nanoparticles (Al NP) are used in applications as diverse as drug delivery, material surface coatings and an ingredient for solid rocket fuel. To understand interactions and biological activity of Al NP in human cells, cultured neonatal epidermal keratinocytes (HEK) were exposed 24 h to 50 and 80 nm NP. HEK viability did not decrease following NP exposure. UV-Vis and NP controls revealed that Al interacts with assay dyes. Our studies illustrate the difficulties involved in assessing the safety of nanomaterials.

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