Zheng Xu, Frederick E. Williams and Ming-Cheh Liu Developmental toxicity of dextromethorphan in zebrafish embryos/larvae Journal of Applied Toxicology 31
The zebrafish was used as a model to investigate the toxicity of dextromethorphan during the embryonic and larval development. Bradycardia and reduced blood flow were observed for the embryos/larvae treated with increasing concentrations of dextromethorphan. Morphological effects of dextromethorphan exposure, including yolk sac and cardiac edema, craniofacial malformation, lordosis, non-inflated swim bladder, and missing gill, were also observed.
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