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Anita Patlolla, Brittney McGinnis and Paul Tchounwou Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss–Webster mice Journal of Applied Toxicology 31

Version of Record online: 24 AUG 2010 | DOI: 10.1002/jat.1579

The aim of this study was to assess the effects, after intra peritoneal injection, of functionalized SWCNTs (carboxyl groups) on reactive oxygen species (ROS) induction and various hepatotoxicity markers (ALT, AST, ALP, LPO and morphology of liver) in the mouse model. The cellular findings reported here do suggest that purified carboxylated functionalized SWCNT has the potential to induce hepatotoxicity in Swiss-Webster mice through the mechanisms of oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.

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