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Xuezhen Zhang, Wei Ji, Huan Zhang, Wei Zhang and Ping Xie Studies on the toxic effects of microcystin-LR on the zebrafish (Danio rerio) under different temperatures Journal of Applied Toxicology 31

Article first published online: 19 NOV 2010 | DOI: 10.1002/jat.1597

Up to now, no in vivo study has been conducted to investigate effects of temperature on MC-induced toxicity in fish, a typical poikilotherm. The LD50 values evidently increased with a decline of the temperature, indicating stronger tolerance of the fish under lower temperature. Changes of the transcription of GST isoforms in the fish were observed, and their sensitivity of response in the transcription of GST mRNA was in the order of 12°C > 32°C > 22°C.

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