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Hyun Jung, Seung-Hyeok Seok, Ju-Hee Han, Tamer Said Abdelkader, Tae-Hyoun Kim, Seo-Na Chang, Ae-Sun Ko, Seung-Kyu Choi, Cho-Rong Lee, Ji-Eun Seo, Soo-Hyun Byun, Jung-A Kim and Jae-Hak Park Effect of fluorescent whitening agent on the transcription of cell damage-related genes in zebrafish embryos Journal of Applied Toxicology 32

Article first published online: 2 MAY 2011 | DOI: 10.1002/jat.1665

7-Diethylamino-4-methylcoumarin (DEMC) is one of fluorescent whitening agents (FWAs) and DEMC-using solutions flow in river and ocean. In this study, we used wild type zebrafish to research about toxicity of DEMC in aquatic environment. High concentration DEMC-treated groups showed several development toxic effects - low survival, hatching and heart rates and high malformations rates. Moreover, DEMC alteration effect of gene expression which related oxidative stress, mitochondrial metabolism and apoptosis in zebrafish embryos.

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