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Jisun Kim, Wonbong Lim, Youngjong Ko, HyukIl Kwon, Sangwoo Kim, Oksu Kim, Gyeongju Park, Hongran Choi and Okjoon Kim The effects of cadmium on VEGF-mediated angiogenesis in HUVECs Journal of Applied Toxicology 32

Article first published online: 21 MAR 2011 | DOI: 10.1002/jat.1677

This study examined the VEGF-dependent mechanisms of angiogenesis and apoptosis in cadmium-treated endothelial cells (HUVECs). As a result, the low concentration of cadmium increased the tube formation in HUVECs. In addition, cadmium at concentrations of 5 μ M and 10 μ M increased VEGF secretion and VEGFR2. However, high concentrations of cadmium caused cell damage, disrupted tube formation and inhibited VEGF expression and the activities of VEGFR2. Therefore, the dual effects of cadmium might alter angiogenesis and induce apoptosis through VEGF pathways in HUVECs.

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