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Shigeaki Takami, Toshio Imai, Young-Man Cho, Kumiko Ogawa, Masao Hirose and Akiyoshi Nishikawa Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks Journal of Applied Toxicology 32

Version of Record online: 28 APR 2011 | DOI: 10.1002/jat.1686

To clarify the general toxicity of acrylamide in the juvenile rats, acrylamide was administered to F344 rats after birth for 12 weeks. Reduction of body weight was noted in 20 and 40 ppm females. Acrylamide-induced histopathological changes were limited to degeneration and necrosis of the seminiferous epithelium in the testes and desquamated epithelium in the epididymides in 40 ppm males. Taken together with previous reports, juvenile rats are not necessarily more susceptible to acrylamide-induced toxicity as compared with young adults.

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