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Luisa Giari, Bahram Sayyaf Dezfuli, Laura Astolfi and Alessandro Martini Ultrastructural effects of cisplatin on the inner ear and lateral line system of zebrafish (Danio rerio) larvae Journal of Applied Toxicology 32

Article first published online: 18 MAY 2011 | DOI: 10.1002/jat.1691

Zebrafish hair cells (HCs) show significant structure, functional and molecular similarities to the mammalian inner ear HCs. We examined the effects of cisplatin, an anti-cancer drug, on HCs of the inner ear and on HCs and support cells (SCs) of neuromasts in Zebrafish larvae. The predominant pattern of injury was widespread degeneration of mitochondria, which appeared swollen and less electron-dense. Severity of damage seemed to be concentration-dependent, and the inner ear suffered more damage than the lateral line system.

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