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Shao-jun He, Jia-fa Hou, Yu-yi Dai, Zhen-lei Zhou and Yi-feng Deng N-acetyl-cysteine protects chicken growth plate chondrocytes from T-2 toxin-induced oxidative stress Journal of Applied Toxicology 32

Version of Record online: 28 JUL 2011 | DOI: 10.1002/jat.1697

In this study, primary cultures of chicken tibial growth plate chondrocytes were treated with T-2 toxin in the absence and presence of N-acetyl-cysteine (NAC) to investigate the effects of NAC on T-2 toxin toxicity. Our results showed that T-2 toxin-induced cytotoxicity was reversed, in part, by antioxidant NAC (P < 0.05), suggesting that T-2 toxin inhibits the proliferation and differentiation of GPCs in vitro by altering cellular homeostasis and NAC can protect GPCs against T-2 toxin cytotoxicity.

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