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Jana Zdarova Karasova, Jaroslav Chladek, Milos Hroch, Fusek Josef, Daniela Hnidkova and Kamil Kuca Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma Journal of Applied Toxicology 33

Article first published online: 30 JUN 2011 | DOI: 10.1002/jat.1699

K027 is a promising new acetylcholinesterase reactivator with low acute toxicity and broad spectrum efficacy. The main aim was to compare the pharmacokinetics of K027 and trimedoxime (single i.m. application, equimolar doses). Near identical plasma profiles were obtained for both compounds. No differences were found in the Cmax mean ± SD values and AUC0-180min. However, the percent coefficient of variation of the first-order rate constant of absorption (ka) was 3-fold higher (p<0.01) providing evidence for more erratic absorption of trimedoxime.

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