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T. H. Umbreit, S. Francke-Carroll, J. L. Weaver, T. J. Miller, P. L. Goering, N. Sadrieh and M. E. Stratmeyer Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice Journal of Applied Toxicology 32

Version of Record online: 25 AUG 2011 | DOI: 10.1002/jat.1700

Tissue distribution and histology of injected titanium dioxide (TiO2) nanoparticles (approximately 120 nm diameter) were assessed in mice up to 26 weeks. Particle agglomerates were observed by light microscopy in the liver, lung and spleen, and in the draining inguinal lymph nodes following s.c. injection. Particles were still observed after 26 weeks. Although no evidence of histopathological damage was observed, the lack of clearance from organs suggests that long-term adverse effects merit examination.

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