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Mandy L. Marziaz, Kathryn Frazier, Paul B. Guidry, Robyn A. Ruiz, Ilona Petrikovics and Donovan C. Haines Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD50 yields insight into the efficacy of prophylactics Journal of Applied Toxicology 33

Article first published online: 13 JUL 2011 | DOI: 10.1002/jat.1709

Cytochrome c oxidase activity in brains excised from mice treated with cyanide and various prophylactic treatments suggests that a recently proposed sulfur donor, thiotaurine, is not as effective as thiosulfate. Further, thiotaurine appeared to inhibit cytochrome c oxidase activity slightly, independent of cyanide treatment. The EC75 for cytochrome c inhibition by cyanide in the different treatment regimens correlated very well with the LD50 determined from mortality data, supporting cytochrome c oxidase inhibition as a major mechanism for cyanide toxicity.

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