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Zhengli Xu, Laisheng Chou and Jiao Sun Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway Journal of Applied Toxicology 32

Article first published online: 15 JUL 2011 | DOI: 10.1002/jat.1710

In the present study, human lung fibroblasts (HFL-Is) were directly exposed to two different sizes of SiO2 nanoparticles. The effect of size and concentration on cell response was studied by analyzing the cell viability, the ratio of apoptosis and the pathway of cell injury. The results demonstrated that a size-associated and a dose-dependent toxicity of HFL-Is was induced by SiO2 nanoparticles.

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