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Domagoj Dinter, Goran Gajski and Vera Garaj-Vrhovac An alkaline comet assay study on the antimalarial drug atovaquone in human peripheral blood lymphocytes: a study based on clinically relevant concentrations Journal of Applied Toxicology 33

Version of Record online: 7 JUL 2011 | DOI: 10.1002/jat.1711

The present study evaluated the cytogenotoxic potential of antimalarial drug atovaquone towards human lymphocytes. Two different clinically relevant concentrations of atovaquone obtained from the plasma concentrations used for prophylactic treatment and the treatment of malaria were used with and without S9 metabolic activation. Atovaquone was not cytogenotoxic in the given concentrations, regardless of metabolic activation. Since no effects were observed after the treatment, it is to be concluded that atovaquone is safe from the aspect of genototoxicity.

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