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Dojung Kim, Young-Joo Lee, Heui-Young Ryu, Jin-Hee Lee, Hyun-Kyung Kim, Eunhee Kim, Jae-Dong Moon, Dong Deuk Chang and Hae-Seong Yoon Genetic polymorphisms in metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine Journal of Applied Toxicology 33

Version of Record online: 1 DEC 2011 | DOI: 10.1002/jat.1712

Heterocyclic amines (HCAs) are naturally produced during cooking processes for meats and fish. Among HCAs, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is classified as ‘reasonably anticipated to be a human carcinogen’. The present study investigated the correlation between human exposure levels of PhIP and the role of genetic polymorphisms of enzymes on PhIP metabolism. The SNPs of CYP1A1/T6235C (MSP I) and CYP1A2/-2467delT showed significant differences in PhIP excretion (P< 0.05). These results could improve understanding of populations subject to PhIP-derived health risk.

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