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Hong-li Chen, Hua Bai, Miao-miao Xi, Riu Liu, Xu-jun Qin, Xin Liang, Wei Zhang, Xiao-di Zhang, Wen-li Li and Chun-xu Hai Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression Journal of Applied Toxicology 33

Article first published online: 5 AUG 2011 | DOI: 10.1002/jat.1713

Phosgene can induce fatal pulmonary edema. Oxidative stress and inflammatory responses are believed to be involved in this process. In the present study, we aim to investigate the therapeutic effects of ethyl pyruvate (EP) on phosgene-induced pulmonary edema and the underlying mechanisms. We found that EP had a protective role against phosgene-induced pulmonary edema, which was mediated in part by inhibiting MAPK activation and subsequently down-regulating COX-2 and iNOS expression as well as decreasing the production of NO and PGE2.

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