Vladimír Kummer, Jarmila Mašková, Zdeněk Zralý and Martin Faldyna Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons Journal of Applied Toxicology 33
Neonates were injected (days 1–14) with benzo(a)pyrene, benz(a)anthracene or benzo(k)fluoranthene and killed on day 23. Exposure to benzo(a)pyrene or benz(a)anthracene increased the number of nonatretic antral follicles and the thecal layer thickness. Disturbed primordial oocytes were only observed after exposure to benzo(a)pyrene. Alterations in ovarian ERβ expression were detected. The response of the ovaries to estradiol in rats exposed to PAHs was suppressed. The study showed that postnatal exposure to PAHs disturbed development of the ovaries and caused ovarian dysfunction.
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