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Imane Abbas, Guillaume Garçon, Françoise Saint-Georges, Véronique Andre, Pierre Gosset, Sylvain Billet, Jérémie Le Goff, Anthony Verdin, Philippe Mulliez, François Sichel and Pirouz Shirali Polycyclic aromatic hydrocarbons within airborne particulate matter (PM2.5) produced DNA bulky stable adducts in a human lung cell coculture model Journal of Applied Toxicology 33

Article first published online: 13 SEP 2011 | DOI: 10.1002/jat.1722

The metabolic activation of polycyclic aromatic hydrocarbons (PAH) within air pollution particulate matter (PM2.5) and PAH-DNA bulky stable adducts in human alveolar macrophage (AM) and/or human lung epithelial L132 cells in mono- and/or in cocultures were studied. Taken together, our relevant results support the exertion of genotoxicity of highly reactive PAH-derived metabolites produced within human AM not only in primary target human AM, but also in secondary target L132 cells.

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