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June Choi, Gi Jung Im, Jiwon Chang, Sung Won Chae, Seung Hoon Lee, Soon-Young Kwon, Ah-Young Chung, Hae-Chul Park and Hak Hyun Jung Protective effects of apocynin on cisplatin-induced ototoxicity in an auditory cell line and in zebrafish Journal of Applied Toxicology 33

Version of Record online: 6 DEC 2011 | DOI: 10.1002/jat.1729

Apocynin, which is used as a specific NADPH oxidase inhibitor, has a preventive effect for intracellular ROS generation. An in vivo study of transgenic zebrafish (Brn3C: EGFP) was used to investigate the protective effects of apocynin on cisplatin-induced hair cell death. In an in vitro study, apocynin appeared to protect against cisplatin-induced apoptotic features on Hoechst 33258 staining in the HEI-OC1 cells. Apocynin has antioxidative effects and prevents cisplatin induced apoptotic cell death in HEI-OC1 cells as well as in zebrafish.

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