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Ritu Tyagi, Poonam Rana, Mamta Gupta, Ahmad Raza Khan, Deepak Bhatnagar, P. J. S. Bhalla, Shubhra Chaturvedi, Rajendra P Tripathi and Subash Khushu Differential biochemical response of rat kidney towards low and high doses of NiCl2 as revealed by NMR spectroscopy Journal of Applied Toxicology 33

Version of Record online: 16 SEP 2011 | DOI: 10.1002/jat.1730

An integrated metabonomic approach, based on high-resolution 1H NMR spectroscopy, was applied to find acute biochemical effects of NiCl2 on renal tissues of rats. The metabolite changes corresponding to nickel exposure are related to amino acids, osmolytes and energy metabolites. Differential responses were observed in 1H NMR spectra of these metabolites with exposure to low and high doses of NiCl2. The present study shows a huge potential of metabonomics for mapping organ-based metabolic response during heavy metal toxicity.

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