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Patrizia Cristofori, Rossella Defazio, Arianna Chiusolo, Michele Mongillo, Giovanni Battista Bartolucci, Federica Chiara and Andrea Trevisan Hyaline droplet accumulation in kidney of rats treated with hexachloro-1:3-butadiene: influence of age, dose and time-course Journal of Applied Toxicology 33

Version of Record online: 12 SEP 2011 | DOI: 10.1002/jat.1732

The occurrence of hyaline droplet (HD) accumulation related to age, dose and time after treatment in male Wistar rats was investigated after a single i.p. injection of hexachloro-1:3-butadiene (HCBD). HD accumulation is greater at 2 months of age, is independent of the dose and shows a time-related accumulation in term of incidence and severity from 6 h after dosing and decreasing at 72 and 96 h. The present results show that HD accumulation is an early finding after HCBD injection

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