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Eun Mi Choi Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells Journal of Applied Toxicology 33

Version of Record online: 9 SEP 2011 | DOI: 10.1002/jat.1733

The effect of deoxyactein isolated from Cimicifuga racemosa on the function of osteoblastic MC3T3-E1 cells was studied. Deoxyactein caused a significant elevation of cell growth, alkaline phosphatase activity, collagen content, and mineralization (P<0.05). Moreover, deoxyactein significantly decreased the production of reactive oxygen species and osteoclast differentiation inducing factors such as TNF-a, IL-6, and receptor activator of nuclear factor-kB ligand in the presence of antimycin A. These results demonstrate that deoxyactein may have positive effects on skeletal structure.

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