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Natasha D. Henry and Patricia A. Fair Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid Journal of Applied Toxicology 33

Version of Record online: 21 SEP 2011 | DOI: 10.1002/jat.1736

MCF-7 BOS human breast cancer cells were used to investigate the potential for cytotoxicity, estrogenicity, and anti-estrogenicity of triclosan, PFOS, and PFOA at environmentally relevant concentrations. Results revealed that both triclosan and PFOA were cytotoxic while PFOS showed no significant cytotoxicity. E-SCREEN testing revealed positive estrogenic activity by all contaminants. Significant anti-estrogenic activity was detected for all compounds when cells were co-exposed with estradiol. The results demonstrated that these contaminants have estrogenic activities and co-exposure with estradiol produced anti-estrogenic effects.

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