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Yanfang Fan, Lan Tang, Juan Zhou, Qian Feng, Bijun Xia and Zhongqiu Liu Simultaneous Determination of Sulfation and Glucuronidation of Flavones in FVB Mouse Intestine in Vitro and in Vivo Journal of Applied Toxicology 33

Article first published online: 15 DEC 2011 | DOI: 10.1002/jat.1737

We investigated the positional preference for sulfation and glucuronidation of seven structurally similar flavones in vitro and in situ. Flavone glucuronidation and sulfation rates were sensitive to minor changes in molecular structure. In intestinal S9 fractions, both Ugts and Sults preferentially catalyzed reactions at 7-OH. The sulfation rate was significantly enhanced by simultaneous glucuronidation, but glucuronidation was unaltered by sulfation.Sulfation rates in mouse S9 fractions correlated with sulfation rates in perfused intestine.

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