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Seref Alpsoy, Cevat Aktas, Ramazan Uygur, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya and Asuman Gedikbasi Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats Journal of Applied Toxicology 33

Version of Record online: 13 OCT 2011 | DOI: 10.1002/jat.1738

The aim of this study was to investigate the antioxidant and anti-apoptotic effects of ACE on DOX-induced cardiotoxicity. Pre-treatment of ACE markedly reduced the reactivity and the amount of cardiomyocyte apoptosis and improved the biochemical parameters in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pre-treatment with ACE. The present study showed that ACE may be a suitable cardio protector against toxic effects of DOX.

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