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Katiane Cella Gabriel, Rafael Rodrigues Dihl, Mauricio Lehmann, Maria Luiza Reguly, Marc François Richter and Heloisa Helena Rodrigues de Andrade Homologous recombination induced by doxazosin mesylate and saw palmetto in the Drosophila wing-spot test Journal of Applied Toxicology 33

Article first published online: 20 OCT 2011 | DOI: 10.1002/jat.1740

Alpha-blockers, as doxazosin mesylate, and 5-alpha reductase inhibitors, as finasteride, decrease both acute urinary retention and the need for benign prostatic hyperplasia (BPH)-related surgery. Saw palmetto has also been used as an alternative to BPH. The activity of these compounds as inducers of different types of DNA-lesions was assessed using SMART test in Drosophila melanogaster. Finasteride was non-genotoxic in our experimental conditions. Doxazosin and saw palmetto were inducers of homologous recombination, an event linked to the loss of heterozygosity.

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