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Ivona Vidić Štrac, Maja Pušić, Goran Gajski and Vera Garaj-Vrhovac Presence of phthalate esters in intravenous solution evaluated using gas chromatography–mass spectrometry method Journal of Applied Toxicology 33

Article first published online: 28 OCT 2011 | DOI: 10.1002/jat.1741

Since application of infusion solutions is one of the most common medical treatments, the objective of this study was to determine the migration of phthalates from softened PVC storage bags into infusion solution in different time periods within one year from date of production using gas chromatography–mass spectrometry. The presence of different phthalate esters leads to the conclusion that the pharmacopeic requirement for polymer cleanness was not fully met.

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