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Maria Efthimiou, Georgia Stephanou, Nikos A. Demopoulos and Sotiris S. Nikolaropoulos Aneugenic potential of the anticancer drugs melphalan and chlorambucil. The involvement of apoptosis and chromosome segregation regulating proteins Journal of Applied Toxicology 33

Version of Record online: 25 OCT 2011 | DOI: 10.1002/jat.1743

It is known that melphalan and chlorambucil exert aneugenic potential mediated through centrosome amplification. To further investigate their aneugenicity we: a) studied whether apoptosis is a mechanism for the elimination of damaged cells generated and b) investigated if chromosome segregation regulating proteins are involved in the modulation of their aneugenicity. We found that: a) apoptosis is not the mechanism of choice for selectively eliminating cells with supernumerary centrosomes and b) the proteins aurora-A, aurora-B and survivin are involved in the modulation of melphalan and chlorambucil aneugenicity.

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