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Grace A. Afolaranmi and M. Helen Grant The effect of ascorbic acid on the distribution of soluble Cr and Co ions in the blood and organs of rats Journal of Applied Toxicology 33

Article first published online: 25 OCT 2011 | DOI: 10.1002/jat.1744

We investigated tissue dissemination of cobalt and chromium ions and determined if administration of ascorbic acid affected their in vivo distribution using rats as a model system. Organs of rats treated with Cr (VI) or Co (II) [but not Cr (III)] had higher metal ion levels when compared with control levels in rats without metal treatment. Prior intraperitoneal injection of ascorbic acid lowered tissue uptake of both Cr VI and Co II, and increased faecal excretion, but not to a significant extent.

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