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Bidisha Mukherjee, Anindita Dutta, Sanghita Roychoudhury and Manas Ranjan Ray Chronic inhalation of biomass smoke is associated with DNA damage in airway cells: involvement of particulate pollutants and benzene Journal of Applied Toxicology 33

Version of Record online: 1 DEC 2011 | DOI: 10.1002/jat.1748

The possibility of DNA damage in sputum cells was examined in 56 premenopausal women who cooked with biomass and 49 matched control who cooked with cleaner fuel. DNA damage was upregulated in biomass users in association with elevated level of urinary t,t-MA, increased ROS generation and depleted SOD along with elevated PM10 and PM2.5 in cooking areas. Thus, biomass smoke causes DNA damage in airway cells, possibly by oxidative stress generated by inhaled pollutants including PM and benzene.

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