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Seref Alpsoy, Ramazan Uygur, Cevat Aktas, Birol Topcu, Mehmet Kanter, Mustafa Erboga, Osman Karakaya and Asuman Gedikbasi The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells Journal of Applied Toxicology 33

Article first published online: 12 OCT 2011 | DOI: 10.1002/jat.1750

The aim of this study was to investigate the effects of ACE on DOX-induced apoptosis in aortic endothelial cells. Pre-treatment of ACE markedly reduced the reactivity and the amount of aortic endothelial cell apoptosis and improved the biochemical parameters in the DOX + ACE group in comparison with the DOX group. Data from our study consider that prevention of endothelial cell apoptosis by ACE may contribute to the restoration of aortic endothelial dysfunction which is associated with DOX treatment.

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