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Jayaraja Sabarirajan, Panneerselvam Vijayaraj, Mary Sarkar and Vasanthi Nachiappan Effect of lipopolysaccharide on alteration of phospholipids and their fatty acid composition in spleen and thymus by in vitro metabolic labeling Journal of Applied Toxicology 33

Version of Record online: 11 NOV 2011 | DOI: 10.1002/jat.1752

Lipopolysaccharide (LPS) is a known endotoxin and a potent immune modulator. LPS induction leads to acute respiratory distress syndrome (ARDS). ARDS is a threatening disease with high mortality rate. The immunological effect of LPS on spleen and thymus is well documented; conversely membrane phospholipid (PL) importance has not yet been studied. We aimed to investigate the influence of LPS on spleen and thymus phospholipid, their fatty acid composition by [32P]-labeling in rats, it showed significant alterations.

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