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Sabry M. Attia Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells Journal of Applied Toxicology 33

Article first published online: 11 NOV 2011 | DOI: 10.1002/jat.1753

The mechanism of genotoxic potential of amsacrine and nocodazole was investigated by micronucleus test complemented by fluorescence in situ hybridization assay using mouse centromeric and telomeric probes. The present study demonstrated for the first time that amsacrine has high incidences of clastogenicity and low incidences of aneugenicity whereas nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases. The assay also showed that chromosomes can be enclosed in the micronuclei before and after centromere separation.

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