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Bo Wang, Shi Wang, Chen Shao, Guangyi Wang, Yang Li and Lu Cai Proteomic characterization of the late and persistent effects of cadmium at low doses on the rat liver Journal of Applied Toxicology 33

Article first published online: 11 NOV 2011 | DOI: 10.1002/jat.1757

Hepatic effects of low-dose cadmium were examined in male Wistar rats given i.p. injection of Cd at 20 nmol kg−1 body weight every other day for 4 weeks. At weeks 20, 44 and 52 after Cd treatment, the livers from Cd-treated and control rats were sampled. Mild histopathological changes, persistent oxidative damage and cell proliferation remained at weeks 44–52. These persistent changes may be associated with the persistent down-regulation of cellular antioxidant systems.

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