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Pietro Ausiello, Angela Cassese, Claudia Miele, Francesco Beguinot, Franklin Garcia-Godoy, Bruno Di Jeso and Luca Ulianich Cytotoxicity of dental resin composites: an in vitro evaluation Journal of Applied Toxicology 33

Article first published online: 26 NOV 2011 | DOI: 10.1002/jat.1765

The purpose of this study was to evaluate the cytotoxic effect of two light cured restorative materials with and without BisGma resin respectively (Clearfil Majesty Posterior, Clearfil Majesty Flow) and a self curing one (Clearfil DC Core Automix) when applied to the fibroblast cell line NIH-3T3. All the composite materials tested caused a decrease of cell proliferation, albeit at different degrees. However, only Clearfil DC Core Automix induced cell death, very likely by increasing apoptosis.

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