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Amel Chatti Gazzah, Luc Camoin, Salwa Abid, Hassen Bacha and Moncef Ladjimi iTRAQ: a method to elucidate cellular responses to mycotoxin zearalenone Journal of Applied Toxicology 33

Version of Record online: 25 JUN 2012 | DOI: 10.1002/jat.1766

The mycotoxin Zearalenone (ZEN) has been associated with a variety of adverse health effects. In order to better understood the mechanism of ZEN toxicity, a proteomic approach, based on the isotope approach iTRAQ, was applied to characterize cellular responses of HepG2 cells to ZEN exposure. This study identified about 982 proteins among which identification and quantification by MALDI-TOF (MS). IPA software was then used to determine the biological functions and canonical pathways associated with the ZEN-responsive proteins.

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