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Benjamin R. Green and Lisa J. Bain Mrp2 is involved in the efflux and disposition of fosinopril Journal of Applied Toxicology 33

Version of Record online: 17 NOV 2011 | DOI: 10.1002/jat.1767

The highly prescribed ACE inhibitor, fosinopril, was 2.4-fold less toxic and was retained at a 4.5-fold lower level in multidrug resistance-associated protein 2 (MRP2)-transfected cells compared with control cells. When fosinopril was coadministered with methoxtrexate, a known MRP2 substrate, its cellular retention was increased in vitro, and fosinopril altered the disposition of methotrexate in vivo. These findings will help increase our understanding of the role that MRP2 plays in altering the retention and disposition of co-administered pharmaceuticals.

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