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Sung Hak Lee, Hong Rye Kim, Rong Xun Han, Reza K. Oqani and Dong Il Jin Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model Journal of Applied Toxicology 33

Version of Record online: 26 NOV 2011 | DOI: 10.1002/jat.1768

Zebrafish serve as an excellent model for assessing drug-induced cardiotoxicity. The cardiovascular risk assessment of six atypical antipsychotic drugs; aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone, was done by zebrafish model. Visual endpoints (llethality, edema, hemorrhage, abnormal body shape and motility) were evaluated as general toxicity endpoints, and the change rate of heart beat as the cardiovascular toxicity endpoint. The zebrafish presents a potentially useful in vivo preclinical model for assessment of the adverse effects of atypical antipsychotic drugs.

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