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Jin-xia Hu, Yan-fang Li, Jing Li, Chen Pan, Zhen He, Hong-yan Dong and Li-chun Xu Toxic effects of cypermethrin on the male reproductive system: with emphasis on the androgen receptor Journal of Applied Toxicology 33

Version of Record online: 6 DEC 2011 | DOI: 10.1002/jat.1769

The adult male rats were treated with different doses of cypermethrin by gavage for consecutive 15 days. The weights of prostates and daily sperm production decreased. Seminiferous tubule changes included atrophy and distortion, reduction and deformation of spermatogonia and spermatocyte. Ultrastructural changes included disrupted cellular junctions, abnormal nucleus, necrosis of spermatogonia, spermatocytes and Sertoli cells. AR expression and serum testosterone reduced. Cypermethrin may impair the seminiferous tubules and spermatogenesis, which can be attributed to the reduced AR expression.

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