Kumiko Ogawa, Toshiya Murasaki, Satoshi Sugiura, Makoto Nakanishi and Tomoyuki Shirai Organ differences in the impact of p27kip1 deficiency on carcinogenesis induced by N-methyl-N-nitrosourea Journal of Applied Toxicology 33
To evaluate the impact of p27 on carcinogenesis in various organs, N-methyl-N-nitrosourea (MNU) was given to p27 knock-out mice. Although the incidences of the lesions in the forestomach, fundic and pyloric glands did not differ among the p27 genotypes, those of the lung and the thymus were significantly increased in p27 null males as compared to both wild and hetero animals. These findings suggest that p27 does not control the cell cycle equally in all organs affected by MNU-induced carcinogenesis.
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