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Audris Chiang, Emilie Tudela and Howard I. Maibach Percutaneous absorption in diseased skin: an overview Journal of Applied Toxicology 32

Version of Record online: 10 JAN 2012 | DOI: 10.1002/jat.1773

The stratum corneum's functions include protection from hazardous environments, water loss prevention and body temperature regulation. While intact skin absorption studies are abundant, studies on compromised skin permeability are less common. We reviewed literature on absorption through abnormal skin models: tape-stripped, abraded, frozen, heated, delipidized, irritated, UV-exposed and diseased skin. Data summarized begins to characterize flux alteration associated with damaged skin. Understanding alteration requires consideration of involved conditions and enlarging our database to a more complete physicochemical spectrum.

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