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Xianting Lu Enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells Journal of Applied Toxicology 33

Version of Record online: 21 JUN 2012 | DOI: 10.1002/jat.1774

The enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells were investigated. The results showed that exposure to 1S-cis-BF resulted in increased transcription of HSP90, HSP70, HSP60, Cu-Zn-SOD, Mn-SOD, CAT and GST, while exposure to 1R-cis-BF and rac-cis-BF exhibited these effects to lesser degrees. Induction of antioxidant enzyme gene expression produced by 1S-cis-BF might occur through activation of p38 MAPK and ERK, while increase of stress protein response might occur through p38 MAPK.

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