Xianting Lu Enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells Journal of Applied Toxicology 33
The enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells were investigated. The results showed that exposure to 1S-cis-BF resulted in increased transcription of HSP90, HSP70, HSP60, Cu-Zn-SOD, Mn-SOD, CAT and GST, while exposure to 1R-cis-BF and rac-cis-BF exhibited these effects to lesser degrees. Induction of antioxidant enzyme gene expression produced by 1S-cis-BF might occur through activation of p38 MAPK and ERK, while increase of stress protein response might occur through p38 MAPK.
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